Research

Ongoing studies @BaloniLab

About Our Research

At the Baloni Lab, our research centers on understanding how environmental exposures interact with genetic and metabolic factors to influence health and disease. We apply systems biology, computational modeling, and multi-omics integration to investigate the molecular mechanisms underlying neurodegenerative disorders, with a primary focus on Alzheimer’s disease. By leveraging transcriptomic, metabolomic, and proteomic data, we develop predictive models and identify key metabolic and signaling pathways disrupted by toxicants. Our interdisciplinary approach combines machine learning, genome-scale metabolic modeling, and network analysis to generate testable hypotheses and guide experimental research. Ultimately, our goal is to uncover biomarkers and therapeutic targets that can inform precision medicine and improve public health outcomes.

Funding: The research is funded by NIA, NIDDK, NIEHS and Showalter Research Trust Award

Ongoing Studies

Study 1

Shifting metabolic landscape in neurodegenerative diseases: focusing on brain cell types, mitochondrial dysfunction, and sex-specific differences

Study 2

Host-microbiome interactions in different dietary conditions

Study 3

Effect of chemical exposure in humans and model organisms